- Transaction Code: 3220-06
- CPT Code (Suggested): 85597
A hexagonal phase phospholipid neutralization procedure is the most sensitive and specific confirmatory assay for the detection of Lupus-like inhibitors. In addition, the Lupus-like Confirmation by STACLOT-LA can detect the presence of Lupus anticoagulant in patients on heparin and/or coumadin.
Lupus-like inhibitors (LLI) are a heterogeneous group of antibodies directed against phospholipid complexed to coagulation proteins (e.g., factor II). Although characterized in vitro by prolongation of coagulation screening tests (especially the APTT) that does not correct upon 1:1 mix, these inhibitors are sometimes associated with recurrent venous and arterial thrombotic disease as well a recurrent mid-gestational abortions. LLI occur not only in patients with systematic lupus erythematosus (SLE), but also in association with drugs, viral infections, AIDS, and in otherwise healthy individuals. Although usually not associated with a hemorrhagic risk, those that have a more specific effect to lower prothrombin or those in which a specific factor VIII autoantibody are present may have abnormal bleeding episodes.
- Sample Required: 0.5 ml frozen plasma x4 or (2) 3.2% sodium citrated tubes, 5 ml each.
- See Sample Requirements when ordered with other tests.
- Normal Test Value: Negative
- Analytic Time: Within 5 working days
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