Hemostasis Reference LaboratoryActivated Partial Thromboplastin Time (APTT)
The activated PTT is a kinetic screening test that measures the recalcification time of plasma after incubation. The APTT assesses the coagulation factors of the intrinsic pathway (factors XII, XI, IX, VIII, X, V, prothrombin, and fibrinogen). The APTT will be prolonged in the presence of a factor deficiency, factor inhibitor, heparin or lupus-like inhibitors. Shortening of the APTT can occur as a result of coagulation factor activation due to a traumatic venipuncture, inadequately processed sample, or disseminated intravascular coagulation (DIC).
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