- Transaction Code: 3230-02
- CPT Code (Suggested): 85303
Protein C is a circulating proenzyme that, upon activation, inhibits coagulation by enzymatically inactivating factors Va and VIIIa. Functional Protein C level is measured using a clotting-based assay in which snake venom-activated protein C prolongs the chromogenic activity of activated clotting factors by inactivating factors Va and VIIIa. Hereditary Protein C deficiency is an autosomal dominant condition associated with a tendency toward venous thromboembolic disease. It is associated with warfarin-induced skin necrosis. Homozygous cases have neonatal purpura fulminans. Acquired protein C deficiency can occur secondary to vitamin K deficiency, warfarin therapy, liver disease and disseminated intravascular coagulation (DIC). Protein C has a short half-life in circulation, comparable to factor VII.
- Sample Required: 0.5 ml frozen plasma x4 or (2) 3.2% sodium citrated tubes, 5 ml each.
- See Sample Requirements when ordered with other tests.
- Normal Range: 60-140%
- Analytic Time: Within 5 working days
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