Jing-Fei Dong Laboratory

The Dong laboratory studies platelets, the smallest cells in blood. This lab seeks to understand how platelets function and how their functions are altered during disease states. Altered platelets may be related to thrombosis (abnormal blood clotting), heart attack, stroke, peripheral artery disease, and cancer. Research on platelets has implications for the management of trauma, heart transplants, and stem cell transplants.

Areas of Study

  • von Willebrand factor (VWF), a large protein that glues platelets together, can form fibrillar structures that may cause thrombosis and inflammation.
  • The regions of ADAMTS-13, an enzyme that cleaves VWF to make less active in causing thrombosis, that are critical for that function.
  • The state of platelets' hyperactivity in patients with peripheral artery disease and how vascular grafts, lipid-lowing drugs, and aspirin affect the clinical outcomes of these patients.
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Dr. Dong's Background

  • Joined the Blood Center in May 2011 to serve as a full member of the Puget Sound Blood Research Institute and Professor of Medicine in the Division of Hematology, Department of Medicine, School of Medicine, University of Washington
  • Since 2003, Dr. Dong has published over 120 peer-reviewed manuscripts in biomedical journals
  • Served as Professor of Medicine and Pediatrics with tenure, Chief of Thrombosis Division in the Department of Medicine and Director of Baylor University Thrombosis Core Laboratory
  • Served as the Associate Director, Graduate Program for Cardiovascular Sciences at Baylor
  • Served as Adjunct Professor in the Department of Bioengineering at Rice University and Acute Care Division, Department of Surgery, University of Texas, Houston Health Science Center
 

Jing-Fei Dong, M.D., Ph.D.
Full Member
Puget Sound Blood Center
Research Institute

Professor of Medicine,
Division of Hematology,
Department of Medicine,
School of Medicine,
University of Washington

Adjunct Professor of Medicine,
Department of Medicine,
Baylor College of Medicine, Houston

Adjunct Professor,
Department of Bioengineering,
Rice University, Houston

Adjunct Professor of Medicine,
Tianjin Medical University, China

Puget Sound Blood Center
Research Institute
1551 Eastlake Avenue E.
Seattle, WA 98102

Email: jfdong@psbc.org
Phone: (206) 568-2200

Rachel A. Sessum
Administrative Specialist
Email: rachels@psbc.org
Phone: (206) 568-2246
Fax: (206) 587-6056