Xiaoyun Fu Laboratory

Research in the Fu lab focuses on disorders related to inflammation and thrombotic diseases, conditions that can be enhanced by our own immune systems. White blood cells respond to local sites of infection by releasing a host of factors capable of destroying invading pathogens and bacteria. One of the immune responses is to generate bacteria-killing oxidants which work just like bleach to "disinfect." However, these powerful oxidants can also damage the surrounding healthy tissue, causing organ and/or blood vessel injury.

Our research uses mass spectrometry and biochemical methods to better understand the pathophysiology (abnormal functional changes) of a wide range of diseases related to inflammation and thrombosis and develop methods for prevention and new therapeutic strategies.

Areas of Study
We seek to understand how oxidants from white blood cells might:

• Control the function of metalloproteases (a family of enzymes) during inflammation
• Regulate the function of blood clotting factors such as von Willebrand Factor and ADAMTS13
• Contribute to damage to the red blood cells during storage and in patients with inflammation
• Read more

Dr Fu's Background

• Joined Puget Sound Blood Center as an associate member in 2008.
• Ph.D. in Chemistry from Zhejiang University (China)
• Served as Professor of Chemistry at Zhejiang University
• Joined the faculty at the University of Washington School of Medicine in 2002

Xiaoyun Fu, PhD
Associate Member
Director of Mass Spectrometry Laboratory

Research Associate
Professor of Medicine
Division of Hematology
University of Washington School of Medicine

Puget Sound Blood Center
Research Institute
1551 Eastlake Avenue E.
Seattle, WA 98102

Email: xiaoyunf@psbc.org
Phone: (206) 568-2250
FAX: (206) 587-6056

Rachel A. Sessum
Administrative Specialist
Email: rachels@psbc.org
Phone: (206) 568-2246
FAX: (206) 587-6056