MHC and Disease Association

• Ramaswami N, Gaur LK, Maldonado M, Hampe C,Rodriguez L, Garza G, Lernmark A, Balasubramanyam A. HLA class II alleles differentiate subgroups of ketosis prone diabetes mellitus (KPDM) and long-term beta cell functional reserve. Diabetes Care 31, 1195-200, 2008
• Balasubramanyam A, Garza G, Rodriguez L, Hampe C, Gaur L, Lernmark Å, Maldonado M. Accuracy and predictive value of classification schemes for ketosis-prone diabetes mellitus (KPDM). Diabetes Care, 29: 2575-2579, 2006.
• Matsumoto S, Iwanaga Y, Okitsu T, Noguchi H, Yonekawa Y, Tanaka K, Strong DM, Reems JA, Gaur LK. Analysis of large-scale nonhuman primate islet isolations. Transplant Proc., 37 (2): 1317-21, 2005
• Gaur LK. Nonhuman primate models for islet transplantation in type 1 diabetes research. ILAR J. 45(3):324-33, 2004
• Agardh E, Gaur LK, Lernmark Å, Agardh CD. HLA-DRB1, -DQA1, and –DQB1 subtypes or ACE gene polymorphisms do not seem to be risk markers for severe retinopathy in younger Type 1 diabetic patients. J Diabetes Complications. 18(1):32-6, 2004
• Maldonado M, Hampe CS, Gaur LK, D’Amico S, Iyer D, Hammerle LP, Bolgiano D, Rodriguez L, Rajan A, Lernmark A, Balasubramanyam A. Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes. J Clin Endocrinol Metab. 88(11):5090-8, 2003.
• Rolandsson O, Hagg E, Janer M, Rutledge E, Gaur LK, Nilsson M, Hallmans G Lernmark Å: High GAD65 autoantibody levels in nondiabetic adults are associated with HLA but not with CTLA-4 or INS VNTR. Journal of Internal Medicine 253 (4): 447-53, 2003.
• Reiner AP, Agardh E, Teramura G, Gaur P, Gaur LK, Agardh CD: Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis. Thromb Haemost 89(1):142-8, 2003.
• Plesner A, Greenbaum CJ, Gaur LK, Ernst RK. And Lernmark A: Macrophages from High Risk HLA DQB1*0201/0302 Type I Diabetes Patients are Hypersensitive to Lipopolysaccharide Stimulation. Scand J Immunol 56(5):522-9, 2002.
• Masewicz SA, Meldrum N, Gersuk V, Gaur LK, Hagopian W, Moriarty L and Nepom GT: Complexity of human immune response profiles for CD4+ T cell epitopes from the diabetes autoantigen GAD65. Autoimmunity, 34: 231-40, 2001.
• Umpierrez GE, Woo W, Hagopian WA, Isaacs SD, Palmer JP, Gaur LK, Nepom GT, Clark WS, Mixon PS, Kitabchi AE: Immunogenetic analysis suggests different pathogenesis for obese and lean African-Americans with diabetic ketoacidosis. Diabetes Care, 22(9):1517-23, 1999.
• Greenbaum CJ, Gaur LK and Noble JA. ICA+ relatives with DQA1*0101/DQB1*0602 have expected 0602 sequence and DR types. J. Autoimmunity 18 (1): 67-70, 2002.
• Parsons KT, Kwok WW, Gaur LK, Nepom GT. Increased frequency of HLA class II alleles DRB1*0301 and DQB1*0201 in lambert-eaton myasthenic syndrome without associated cancer. Hum Immunol. 61(8):828-33, 2000.
• MacDonald KS, Fowke KR, Kimani J, Dunand VA, Nagelkerke NJD, Ball TB, Oyugi J, Njagi E, Gaur LK, et al.: Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection. J Infect Dis. 181(5):1581-9, 2000.
• Gaur LK, Peeling RW, Cheang M, Kimani J, Bwayo J, Plummer F, Brunham RC: Association of Chlamydia trachomatis heat-shock protein 60 antibody and HLA class II DQ alleles. J Infect Dis. 180(1): 234-7, 1999.
• Agardh D, Agardh E, Landin-Olsson M, Gaur LK, Agardh C-D and Lernmark Å.: Inverse relationship between GAD65 antibody levels and severe retinopathy in younger type 1 diabetic patients. Diabetes Res Clin Pract. 40:9-14, 1998.
• Agardh, D, Gaur LK, Agardh E, Landin-Olsson M, Agardh C-D, Lernmark, Å: Severe retinopathy in insulin-dependent diabetes mellitus is associated with HLA-DQ. Diabetologia 39:1313-1317, 1996.
• Leech, NJ., Kitabchi, A.E., Gaur, LK., Hagopian, W., Hansen, J., Burghen, G., Palmer, J.P. and Nepom, G.T.: Genetic And Imunological Markers Of Insulin Dependent Diabetes In American Blacks. Autoimmunity, 22:27-32, 1995

Transfusion, Transplantation, Stem Cells and Tolerance

• Shields LE, Gaur L, Delio P, Gough M, Potter J, Sieverkropp A, Andrews RG. The use of CD 34(+) mobilized peripheral blood as a donor cell source does not improve chimerism after in utero hematopoietic stem cell transplantation in non-human primates. J Med Primatol. 34(4):201-8, 2005.
• Sieverkropp AJ, Andrews RA, Gaur L, Shields LE. Chimerism analysis by sex determining region Y (SRY) and major histocompatibility complex markers in non-human primates using quantitative real-time polymerase chain reaction. Tissue Antigens, 66 (1): 19-25, 2005
• Shields LE, Gaur LK, Delio P, Potter J, Sieverkropp A, and Andrews RG. Fetal Immune Suppression as Adjunctive Therapy for In Utero Hematopoietic Stem Cell Transplantation in Nonhuman Primates. Stem Cells, 22:759-769, 2004.
• Slichter SJ, Fish D, Abrams VK, Gaur LK, Nelson K, Bolgiano D. Evaluation of different methods of leukoreduction of donor platelets to prevent alloimmune platelet refractoriness and induce tolerance in a canine transfusion model. Blood. 15;105(2):847-54, 2005
• He J-Q, Robert L. Carithers Jr, Karen Nelson, Lakshmi K. Gaur. Cytokine gene polymorphisms are associated with hepatitis C virus induced end-stage liver disease. Hepatology, 38(4 Suppl. 1): 536A, 2003. (Abstract)
• He J-Q, Nelson K, Carithers RL Jr, Gaur LK. Association of HLA-DRB1 and DQB1 polymorphisms with severe hepatitis C virus infection. Hepatology, 38(4 Suppl. 1): 528A-529A, 2003. (Abstract)
• He J-Q, Nelson K, Larson AM, Carithers RL Jr, Perkins JD, Gaur LK. Association of TNFalpha and IL10 promoter polymorphisms with rejection after liver transplantation in aucasian HCV patients. Hum Immunol. 64(10 Suppl):S52, 2003. (Abstract)
• He J-Q, Nelson K, Carithers RL, Larson AM, Perkins JD, Gaur LK. Association of HLA class I alleles with recurrence of hepatitis C virus infection after liver transplantation. Hum Immunol. 64(10 Suppl):S69, 2003 (Abstract)
• He J-Q, Nelson K, C, Larson AM, Parkins JD, Gaur LK. Donor-recipient sharing of HLA class II alleles predicts earlier recurrence of HCV following liver transplantation. Hum Immunol. 64(10 Suppl):S69, 2003. (Abstract)
• Shields LE, Gaur LK, Gough M, Potter J, Sieverkropp A, Andrews RG. In utero hemato-poietic stem cell transplantation in nonhuman primates: the role of T cells. Stem Cells, 21(3):304-14, 2003.
• Cohen CR, Gichui J, Rukaria R, Sinei SS, Gaur LK, Brunham RC: Immunogenetic correlates for Chlamydia trachomatis-associated tubal infertility. Obstet Gynecol. 101(3): 438-44, 2003.
• Kuhr CS, Nelson K, Gaur L, Marsh CL: Induced microchimerism by spleen reperfusion affords no immunological advantage in pancreas transplantation. Transplant Proc. 35(2): 878-9, 2003.
• He JQ, Gaur LK, Stempien-Otero A, Nelson K, Levy WC, O’Brien KD, Bolgiano DC, Reiner APJ: Genetic variants of the hemostatic system and development of transplant coronary artery disease. Heart Lung Transplant. 21(6):629-36, 2002.
• LK Gaur Y Nitta E Kennedy, Å Lernmark, KA Nelson, M Allen, GT Nepom. Induction Of Islet Allotolerance In Non-Human Primates Ann N Y Acad Sci. 958: 199-203, 2002.
• LK Gaur E Kennedy, Y Nitta, GT Nepom, KA Nelson, M Allen. And Å Lernmark. Induction Of Donor Specific Tolerance To Islet Allografts In Nonhuman Primates. Ann N Y Acad Sci. 958: 194-198, 2002.
• Reiner AP, Schwartz SM, Frank, MB, Longstreth WB Jr, Hindorff LA, Teramura G, Rosendaal, FR, Gaur LK, Psaty BM, Siscovick, DS. Polymorphisms of coagulation factor xiii subunit a and risk of non-fatal hemorrhagic stroke in young white women. Stroke 32 (11): 2580-7, 2001.
• Gaur LK, Nepom GT and Lernmark Å: Low-dose Streptozotocin induces sustained hyperglycemia in Macaca nemestrina, Autoimmunity 33: 103-114, 2001.
• Nitta Y, Gaur LK, Nelson K, de Fries-Hallstrand R, Thomas R, Andrews RG, Allen MD. Intrathymic donor stem cell fractions increase chimerism but do not check alloantibody or alloreactivity responses in nonhuman primates. Transplant Proc. 33(1-2):110-1, 2001.
• Nitta Y, Nelson K, Andrews RG, Thomas R, Gaur LK, Allen MD. CFSE dye dilution mixed lymphocyte reactions quantify donor-specific alloreactive precursors in non-human primate cardiac graft rejection. Transplant Proc. 33(1-2):326-9, 2001.
• Cotler SJ, Gaur LK, Gretch DR, Wile M, Strong DM, Bronner MP, Carithers RL Jr, Emond MJ, Perkins JD, Nelson KA: Donor-recipient sharing of HLA class II alleles predicts earlier recurrence and accelerated progression of hepatitis C following liver transplantation. Tissue Antigens 52(5):435-43, 1998.
• Reiner AP, Aramaki KM, Teramura G, Gaur LK. Analysis of Platelet Ia (a2 integrin) allele frequencies in three north aucasia populations reveals genetic association between nucleotide 807C/T and amino acid 5050 Glu/Lys (HPA-5) dimorphisms. Thromb Haemost, 80:449-56, 1998.
• Allen MD, Weyrich J, Akimoto H, Gaur LK, Thomas R, Hall J, Nelson K, Andrews RG. Intrathymic CD34+ marrow implants in primates result in microchimerism without immunosuppression Cellular Immunol. 181:127-138, 1997.
• Weyrich JT, Andrews RG, Nelson K, Gaur LK, Akimoto H, Thomas R, Hall J and Allen MD.: Intrathymic stem-cell transplantation produces hematopoietic microchimerism in human to baboon xenografts. Transplant. Proc. 28(2): 760, 1996.

MHC: Polymorphism and Function

• Polymorphism and function Gaur LK, Pandarpurkar M, Anderson J. DQA-DQB linkage in old world monkeys. Tissue Antigens, 51:367-373, 1998.
• Gaur LK, Nepom G T, Snyder KE, Anderson J, Pandarpurkar M, Yadock W and Heise R: MHC-DRB allelic sequences incorporate distinct intragenic trans-specific segments. Tissue Antigens, 49:342-355, 1997.
• Gaur L.K. and Nepom, G. T.: Ancestral MHC-DRB genes beget conserved patterns of localized polymorphisms. Proc. Natl. Acad.Sci. USA 93:5380-5383, 1996.
• Gaur L.K.: “Nomenclature for factors of HLA system, 1994” A few suggestions. Letter to the Editor. Tissue Antigens, 47:163, 1996.
• Gaur L.K., Shewey, L.M., Sharkey-Mathis, D. and Nepom, G.T. Transcriptional regulatory elements in primate MHC-DQB genes. Transgenics 1:267-276, 1994.
• Gaur LK and Anderson, J: Allelic diversity of MHC-DRB and –DQB in prosimians. Hum. Immunol. 40 (suppl.1):76, 1994.
• Gaur LK. And Anderson, J.E. Prosimian MHC-DQB polymorphisms. Exp. Clin. Immunogenet. 11(1):45-52, 1994.
• Gaur LK, Andersen JA, Montero, RP: Generation and maintenance of MHC class II polymorphism. Hum. Immunol. 34 (suppl. 1):106, 1992