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Research: Latchman Lab Publications

Hind C.R.K., Griffin J.F., Pack S., Latchman Y.E., Drake H.F., Jones H.M., Brostoff J., Dormandy T.L.J. and Treasure T. Effect of cardiopulmonary bypass on circulating concentrations of leucocyte elastase and free radical activity. Cardiovascular Research 1988; 22: 37-41.

Hind C.R.K., Latchman Y.E. and Brostoff, J. Circulating human leucocyte elastase levels in patients with pulmonary sarcoidosis. Sarcoidosis 1988;  5: 38-42.

Krayenbuhl M.C., Hudspith B.N., Brostoff J., Scadding G.K., Guesdon J.L. and Latchman Y.E. Nasal Histamine release following hyperosmolar and allergen challenge. Allergy 1989; 44: 25-29

Brightman C.A.J., Scadding G.K., Dumbreck L.A., Latchman Y.E. and Brostoff J. Yeast derived hepatitis B vaccine and yeast sensitivity. Lancet 1989; I: 903.

Jakob T., Hudspith B.N., Latchman Y.E., Rycroft R. and Brostoff, J. Depressed lymphocyte transformation and the role of prostaglandins in atopic dermatitis. Clin. Exp. Immunol 1990; 79: 380-384.

Bungy Poor Fard G.A., Latchman Y.E., Rodda S., Geysen M., Roitt, I. and Brostoff J. T cell epitopes of the major fraction of rye grass Lolium perenne (Lol p1) defined using overlapping peptides in vitro and in vivo.1. Isoallergen clone 1A. Clin.Exp. Immunol 1993; 94: 111-116.

Latchman Y.E., Whittle B., Rustin M.H.A., Atherton D.J. and Brostoff J. The efficacy of traditional Chinese herbal therapy in atopic eczema. Int. Arch. Allergy Immunol 1994; 104: 222-226.

Latchman, Y.E. and Brostoff .J. The effect of prednisolone on IL-4 and IL-13 induced CD23 expression on U937 cells and peripheral blood monocytes. Immunology 1994; 83 Suppl 1:62.

Latchman Y.E., Bungy G.A., Atherton D.J., Rustin M.H.A. and Brostoff J. Efficacy of traditional Chinese herbal therapy in vitro. A model system for atopic eczema: inhibition of CD23 expression on blood monocytes. Br J Dermatol 1995; 132:592-598.

Latchman Y.E., Banerjee P., Poulter L.W., Rustin M. and Brostoff. J. Association of immunological changes with clinical efficacy in atopic eczema patients treated with traditional Chinese herbal therapy (ZemaphyteTM) Int. Arch. Allergy. Immunol. 1996; 109:243-249.
Latchman Y.E. and Reiser H. Engagement of murine CD2 by its ligand CD48 leads to enhanced CD4 T cell responses. Eur. J. Immunol. 1998; 28:4325-4331.

Latchman Y.E., McKay P.F. and Reiser H. Identification of the 2B4 molecule as a counter-receptor for CD48. J. Immunol (Cutting Edge) 1998; 161:5809-5812.

González-Cabrero J., Wise C.J., Latchman Y.E., Freeman G.J., Sharpe A.H. and Reiser H. CD48-deficient mice have a pronounced defect in CD4 T cell activation. Proceedings of the National Academy of Science 1999; 96: 1019-1023.

Latchman Y.E., Wood C.R., Chernova T., Chaudhary D., Borde M., Chernova I., Iwai Y., Long A.J., Brown J.A., Nunes J., Greenfield E.A., Bourque K., Boussiotis V.A., Carter L.L., Carreno B., Malenkovich N., Nishimura H., Okazaki T., Honjo T., Sharpe A. H. and Freeman G.J. PDL2 is a second ligand for PD1 and inhibits T cell activation. Nature Immunology 2001; 2: 261-268.

Greenwald R.J., Latchman Y.E. and Sharpe A.H. Negative co-receptors on lymphocytes. Current Opinion Immunology 2002; 14: 391-396.

Liang S.C., Latchman Y.E., Buhlmann J.E., Tomczak M. F., Horwitz B.H., Freeman G.J and Sharpe A.H. Regulation and comparison of PD-1, PD-L1, and PD-L2 expression Eur J Immunol 2003; 33:2706-2716.

Latchman Y.E., Liang S.C., Wu Y., Chernova T., Sobel R.A., Kleem M., Kuchroo V.J., Freeman G.J and Sharpe A.H. PD-L1 Deficient Mice show that PD-L1 on T Cells, APC and host tissues negatively regulates T cells PNAS (Track II) PNAS 2004; 101:10691-10696.

Keir M.E., Latchman Y.E., Freeman G.J and Sharpe A.H. PD-1:PD-L1 interactions inhibit TCR-mediated positive selection in thymocytes J Immunol  2005;175:7372-9.

Greenwald J.M., Liang S.C., Latchman Y.E., Rosas L., Satoskar A., Freeman G.J and Sharpe A.H. PD-L1 and PD-L2 have distinct roles in regulating Th cell responses and host immunity to cutaneous leishmaniasis. Eur J Immunol 2006; 36:58-64.

Abadia-Molina A.C., Ji H., Faubion W.A., Julien A., Latchman Y.E., Yagita H., Sharpe A.H. , Bhan A.K., and Terhorst C. CD48 controls T cell and antigen presenting cell functions in experimental colitis. Gastroenterology 2006; 130:424-434

Lee K., Forman J., McNerney M., Stepp S., Kuppireddi S., Guzior D., Wei H., Latchman Y.E., Sayegh M.H., Yagita H., Wulfing C., Schatzle J., Mathew P.A., Sharpe A.H. and Kumar V. Homotypic NK cell interaction through 2B4/CD48 pair regulates the development of NK effector function . Blood 2006; 107:3181-3188.

Keir M.E., Liang S.C ., Guleria I., Latchman Y.E., Qipo A., Albacker L.A., Koulmanda M., Freeman G.J., Sayegh M and Sharpe A.H. Tissue expression of PD-L1 mediates peripheral T cell tolerance. JEM 2006; 203: 883-95.