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I have worked on Human Islet Transplantation in Seattle (HITS) program in improvement of human pancreatic islet isolation for clinical transplantation and research, and generation of pancreatic beta cells through proliferation and differentiation of adult human pancreatic islet cells and fetal pancreatic cells for the past years. This work was supported by the National Center for Research Resources (NCRR)/National Institutes of Health (NIH).
We have been working on developing methods for the production of functional platelets in vitro that could be used for clinical transfusion. My current research has focused on developing methods for the expansion of megakaryocytes (MKs) from bone marrow or umbilical cord blood derived progenitors; promoting thrombopoiesis of MKs and megakaryocytic cell lines in vitro; and testing function of platelets produced from hematopoietic progenitors and/or MK cell lines. This work is a part of the Specialized Centers of Clinically Oriented Research (SCCOR) Project II. |
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