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Research: Thompson Lab Publications

Weinmann AF, Murphy MEP and Thompson AR: Consequences of factor IX mutations in 26 families with haemophilia  B. Br. J. Haematol. 100:58-61, 1998.

Liu M-L, Murphy MEP and Thompson AR: A domain mutations in 65 hemophilia A families and molecular modeling of dysfunctional factor VIII proteins.  Br. J. Haematol. 103:1051-1060, 1998. 

Liu M-L and Thompson AR: Factor VIII gene inversions and an XbaI polymorphism: non-radioactive detection and clinical usage.  Haemophilia 5:26-31, 1999.

Miao CH, Ohashi K, Patijn GA, Meuse L, Ye X, Thompson AR and Kay MA:  Inclusion of the hepatic locus control region, an intron and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitroMolec. Therapy 1:522-532, 2000. 

Liu M-L, Shen BW, Nakaya S, Pratt KP, Fujikawa K, Davie EW, Stoddard BL and Thompson AR:  Hemophilic factor VIII C1 and C2 domain missense mutations and their modeling to the 1.5 Å human C2 domain crystal structure.  Blood 96:979-987, 2000.  

Nakaya S, Liu M-L and Thompson AR:  Factor VIII exon 14 frameshift mutations can cause moderately severe hemophilia A.  Br. J. Haematol. 115:977-982, 2001.

Liu M-L, Nakaya S and Thompson AR:  Non-inversion factor VIII mutations in 80 haemophilia A families including 24 with alloimmune responses. Thromb. Haemost. 87:273-276, 2002. 

Liu M-L and Thompson AR:  Factor VIII's C1 domain enhances C2 binding of factors IX/IXa, X/Xa and von Willebrand factor (vWF).  Blood 96:489a, 2000. (abst)

Liu M-L and Thompson AR:  Vitamin K-dependent hemostatic proteins bind to recombinant C1C2 domain of factor VIII.  Thromb. Haemost. 86 (Suppl):P1360, 2001. (abst)

Manno CS, Chew AJ, Hutchison S, Larson PJ, Herzog RW, Arruda VR, Jen Tai S, Ragni MV, Thompson AR, Ozelo M, Couto LB, Leonard DGB, Johnson FA, McClelland A, Scallan C, Skarsgard E, Flake AW, Kay MA, High KA and Glader B:  AAV-Mediated Factor IX Gene Transfer to Skeletal Muscle in Patients with Severe Hemophilia B.  Blood 101:2963-2972, 2003.

Hsu T-C, Pratt KP and Thompson AR:  Recombinant Factor VIII C1C2 Domain Expressed in E.coli.  J. Thromb. Haemost. Suppl 1, P1065, 2003.

Ye X, Stafford DW, Thompson AR, Miao CH: Complete and sustained phenotypic correction in hemophilia B mice after hepatic gene transfer of a high-expressing human factor IX plasmid.  Thromb. Haemost.1:103-11, 2003.

Ye P, Thompson AR, Sarkar R, Shen Z, Lillicrap DP, Kaufman RJ, Ochs HD, Rawlings DJ and Miao CH:  Naked DNA Transfer of Factor VIII Induced Transgene-Specific, Species-Independent Immune Response in Hemophilia A Mice.  Mol. Therapy 10:117-126, 2004.

Thompson AR, Gill JC, Ewenstein BM, Mueller-Velten G and Schwartz BA for the Humate-PÒ Study Group: Successful Treatment for Patients with von Willebrand Disease (vWD) Undergoing Urgent Surgery Using Factor VIII/VWF Concentrate (Humate-P©).  Haemophilia 10:42-51, 2004.

Thompson AR:  Supple to Stiff.  Blood 103:7, 2004 (Invited Commentary)

Nakaya SN, Hsu T-C, Geraghty SJ, Manco-Johnson MJ and Thompson AR:  Severe Hemophilia A Due to a 1.3 kb Factor VIII Gene Deletion Including Exon 24: Homologous Recombination between 41bp within an Alu Repeat Sequence in Introns 23 and 24.  J. Thromb. Haemost. 2:1941-1945, 2004.

Lillicrap D and Thompson AR:  Gene Therapy for the Hemophilias.  Haemophilia 10 (Suppl 1):1-11, 2004.

Thompson AR:  When All Else Fails to Stop Massive Bleeding from Trauma.  J. Thromb. Haemost. 3:638-639, 2005. (Invited Commentary)

Thompson AR:  Concentrated von Willebrand Factor for Treating Patients with von Willebrand Disease.  Haematologica Reports 1:32-37, 2005.

Sahud MA, Pratt KP, Zhukov O, Qu K, Nakaya SM and Thompson AR:  ELISA for Detecting Immune Responses to Factor VIII.  J. Thromb. Haemost. 3(Suppl 1):P2016, 2005. (abst)

Hsu T-C, Nakaya SM and Thompson AR:  Severe Hemophilia B Due to a 6kb Deletion Including Exon 4, Due to Non-Homologous Recombinatin and Associated with Dysfunctional Protein Missing the Firs EGF-like Domain.  J. Thromb. Haemost. 3(Suppl 1):P0822, 2005. (abst)

Pratt KP, Shima MK, Jacquemin M, Davie EW and Thompson AR:  Mapping of B Cell Epitopes on the Factor VIII C2 Domain.  J. Thromb. Haemost. 3(Suppl 1):P1843, 2005. (abst)

Johnson M, Thompson A (updated August 2005) Hemophilia A in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online].  Available at http://www.geneclinics.org/profiles/hemo-a/.

Johnson M, Thompson A (updated August 2005) Hemophilia B in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online].  Available at http://www.geneclinics.org/profiles/hemo-b/.

Bajaj SP and Thompson AR:  Factor IX.  In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice (5th ed), Colman RW, Hirsh J, Marder VJ, Clowes AW and George JN, eds.  Lippincott-Raven Publishers, Philadelphia, PA, Chapter 7, in press, 2005.

Thompson AR:  Congenital Bleeding Disorders from Other Coagulation Protein Deficiencies.  In: Clinical Hematology, Young NS, Gerson SL and High KA, eds.  Elsevier, Philadelphia, PA, Chapter 66, in press, 2005.

Thompson AR:  Concentrated von Willebrand Factor to Treat or Prevent Bleeding: Indications and Use.  Hemophilia 12:in press, 2006. (abst)

Thompson AR, Nakaya SM, Johnson MJ:  Genotype and inhibitors in hemophilia A.  Hemophilia 12:in press, 2006. (abst)

Thompson AR, Cooper C, Killian RM:  Ethical Issues in Gene-Based Diagnosis for Patients with Congenital Bleeding Disorders.  Hemophilia 12:in press, 2006. (abst)

Miao CH, Ye P, Thompson AR, Rawlings DJ and Ochs HD:  Immunomodulation of Transgene Responses Following Naked DNA Transfer of VIII into Hemophilia A Mice.  Submitted, 2005.