Blood Component Therapy
Cryoprecipitate is available in pre-pooled concentrates of six units. Each unit from a separate donor is suspended in 15 mL plasma prior to pooling. For use in small children, up to 4 single units can be ordered. Each unit provides about 350 mg of fibrinogen.
Indications for Cryoprecipitate
Usage and Therapeutic Effect
Cryoprecipitate - Dosage
In a 70 kg Patient:
Fibrinogen replacement: Effect can be monitored by fibrinogen
Pediatric dosing for cyroprecipitate is 1 unit per 10kg child,
To replace factor VIII or von Willebrand factor: When specific factor concentrates are unavailable, the usual adult dose is a pool of 6 - 12 bags. Approximately 150 units of factor VIII and von Willebrand factor are provided per bag. A single donor may be used repeatedly for a young or mildly affected patient to limit donor exposures.
Fibrin glue:Although single units of cryoprecipitate are available for use in the preparation of fibrin glue to be applied locally for surgery, commercially available, virally inactivated concentrates have a higher fibrinogen concentration and are preferred for this purpose (Tisseel®). A patient may donate autologous plasma for processing into cryoprecipitate prior to a planned surgical procedure.
|Blood Component Therapy
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